Risks of Clenbuterol

razg · 14-04-2006, 08:53 PM

I decided to do some research after hearing tales of Clenbuterol related heart damage - those of you who realise the importance of research may find this useful.

And for those of you who don't care about your heart, take note that it has also been shown to damage skeletal muscle tissue also.

The research is reverse chronologically listed with the newest study being from 2006.

Quote:

Myotoxic effects of clenbuterol in the rat heart and soleus muscle.

Burniston JG, Ng Y, Clark WA, Colyer J, Tan LB, Goldspink DF.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 2ET, United Kingdom. hhsjburn@livjm.ac.jp

Myocyte-specific necrosis in the heart and soleus muscle of adult male Wistar rats was investigated in response to a single subcutaneous injection of the anabolic beta(2)-adrenergic receptor agonist clenbuterol. Necrosis was immunohistochemically detected by administration of a myosin antibody 1 h before the clenbuterol challenge and quantified by using image analysis. Clenbuterol-induced myocyte necrosis occurred against a background of zero damage in control muscles. In the heart, the clenbuterol-induced necrosis was not uniform, being more abundant in the left subendocardium and peaking 2.4 mm from the apex. After position (2.4 mm from the apex), dose (5 mg clenbuterol/kg), and sampling time (12 h) were optimized, maximum cardiomyocyte necrosis was found to be 1.0 +/- 0.2%. In response to the same parameters (i.e., 5 mg of clenbuterol and sampled at 12 h), skeletal myocyte necrosis was 4.4 +/- 0.8% in the soleus. These data show significant myocyte-specific necrosis in the heart and skeletal muscle of the rat. Such irreversible damage in the heart suggests that clenbuterol may be damaging to long-term health.

PMID: 12381771 [PubMed - indexed for MEDLINE]

Quote:

Characterization of adrenoceptor involvement in skeletal and cardiac myotoxicity Induced by sympathomimetic agents: toward a new bioassay for beta-blockers.

Tan LB, Burniston JG, Clark WA, Ng Y, Goldspink DF.

Academic Unit of Molecular Vascular Medicine, University of Leeds, England.

Excessive levels of catecholamines have long been known to be cardiotoxic, but less well known are their toxic effects on skeletal muscle. By using an antimyosin monoclonal antibody and quantitative methods to measure the extent of myocyte necrosis, and by employing modulators of adrenoceptors (ARs), including clenbuterol, bupranolol, propranolol, bisoprolol, atenolol, ICI-118551, phenoxybenzamine, prazosin, and yohimbine, the involvement of ARs in isoproterenol-induced myotoxicity was characterized. In the myocardium, the toxic effects were predominantly mediated via the beta(1)-ARs. In the soleus muscle, it was almost solely via the beta(2)-ARs. Myotoxicity was also observed in the myocardium when challenged with the beta(2)-AR agonist clenbuterol. This was found to be mediated via sympathetic presynaptic beta(2)-ARs, leading to enhanced release of norepinephrine. This effect was abolished by prior treatment with reserpine. The skeletal muscle was found to be more sensitive to the myotoxic effects than cardiac muscle at lower doses of beta-AR agonists. These experiments introduce a new way of assaying beta-AR antagonists by classifying them according to their ability to prevent catecholamine-induced myotoxicity. Further research along these lines may deepen understanding of which beta-blockers work best in heart failure therapy.

PMID: 12658052 [PubMed - indexed for MEDLINE]

Quote:

Dose-dependent separation of the hypertrophic and myotoxic effects of the beta(2)-adrenergic receptor agonist clenbuterol in rat striated muscles.

Burniston JG, Clark WA, Tan LB, Goldspink DF.

Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Webster Street, Liverpool L3 2ET, UK.

Muscle growth in response to large doses (milligrams per kilogram) of beta(2)-adrenergic receptor agonists has been reported consistently. However, such doses may also induce myocyte death in the heart and skeletal muscles and hence may not be safe doses for humans. We report the hypertrophic and myotoxic effects of different doses of clenbuterol. Rats were infused with clenbuterol (range, 1 mug to 1 mg.kg(-1)) for 14 days. Muscle protein content, myofiber cross-sectional area, and myocyte death were then investigated. Infusions of >/=10 mug.kg(-1).d(-1) of clenbuterol significantly (P < 0.05) increased the protein content of the heart (12%-15%), soleus (12%), plantaris (18%-29%), and tibialis anterior (11%-22%) muscles, with concomitant myofiber hypertrophy. Larger doses (100 mug or 1 mg) induced significant (P < 0.05) myocyte death in the soleus (peak 0.2 +/- 0.1% apoptosis), diaphragm (peak 0.15 +/- 0.1% apoptosis), and plantaris (peak 0.3 +/- 0.05% necrosis), and significantly increased the area fraction of collagen in the myocardium. These data show that the low dose of 10 mug.kg(-1).d(-1) can be used in rats to investigate the anabolic effects of clenbuterol in the absence of myocyte death. Muscle Nerve, 2006.

PMID: 16411205 [PubMed - in process]

funbos · 15-04-2006, 01:00 AM

one of my dogs was eat one box/plastic jar of jing tan clen ( IMO the best on the market )

i was afraid for him but now all its ok with him

razg · 15-04-2006, 01:02 AM

LOL.

Reminds me of "My dog ate my dbol" thread - dogs are amazingly tough creatures.

Nick500 · 15-04-2006, 01:16 AM

Sideeffects of Clen (another source...):

Clenbuterol is a popular - but banned - drug used by athletes in body-building, power-related, and even endurance sports. The chemical is attractive to athletes because it appears to have an anabolic effect on human muscles, and it may also increase fat metabolism. However, the actual effects of long-term clenbuterol intake on performance, muscle power, and overall health have been unclear.

To determine some of clenbuterol's actions, scientists at the University of Melbourne in Australia recently gave clenbuterol to laboratory rats at dosages of 2 milligrams per kilogram of body weight per day. Some of the rats followed a completely sedentary lifestyle, while others sprinted on treadmills or engaged in endurance swim training. Clenbuterol did have a couple of potentially positive effects: Sedentary rats which ingested clenbuterol had larger muscles than clenbuterol-free, sedentary rodents, and clenbuterol users also transformed leg-muscle cells from slow-twitch to fast-twitch fibres, a surprising change which would tend to increase anaerobic energy production and magnify muscle power during short, intense exertions.

However, clenbuterol also yielded three very negative changes. First, after just four weeks, clenbuterol-treated rats were unable to maintain their normal swimming or running training intensities, while clean rodents were quite capable of continuing. Secondly, the hearts of the clenbuterol-taking, trained rats increased dramatically in size compared to the hearts of sedentary rats, but the heart expansion was probably due to the infiltration of collagen fibres into the heart walls, not an increase in heart-muscle cells. Collagen is a tough connective tissue which doesn't augment heart-muscle power but in fact stiffens the heart, potentially leading to a decrease in cardiac output. Increases in collagen may also produce cardiac arrhythmias. Thirdly, clenbuterol rats suffered from noticeable cardiac-cell degeneration.

In addition, although sedentary, clenbuterol-treated rats were more muscular than clenbuterol-free, sedentary rats, clenbuterol was unable to boost muscle mass among either the swim- or treadmill-trained rodents. It appears that, in spite of its popularity, clenbuterol is a potentially dangerous drug which offers very few positive effects for either the power or endurance athlete.

('The Effects of Clenbuterol on Skeletal and Cardiac Muscle of Rats when Combined with Aerobic and Anaerobic Exercise, ' Biochemistry of Exercise Ninth International Conference Abstracts, #117, p 75, 1994)

Young Gun · 15-04-2006, 03:39 PM

Another for the I don't care locker. I don't see people dropping dead from clen induced heart attacks and I could get about 5 studies to show that the levels of potassium in banana's are a potential cancer risk.

At the end of the day the only people at a serious risk from drug abuse is those who abuse them. Bodybuilding use IMO is nowhere near abuse, maybe I should do a check to find out how likely it is that I may be in a car accident on the way to buy it?

***Extreme*** · 17-04-2006, 12:51 AM

Ok, can I nail this thread shut?

What dose of clen do people commonly use? 0.4mcg up to 2mcg PER PERSON!

The doses of stuff they give these rats is bound to fukk em up, its ridiculous and not even worth comparing to that being used in the real world of performance/aesthetic enhancement.

www.extremenutrition.co.uk

Caymen · 17-04-2006, 02:21 AM

To put it short Clen put me in hospital with suspected heart attack at 18 years old, very low dose also, the Cardiologist told me that my heart wasnt pumping blood properly because of the effect clen was having on me, im just one of the unlucky ones that dont get along with clen.

we shouldnt live in a state of denial were steroids and related compounds are concerned!, they can have a negative effect on some people were the majority get away with it but we all need to have respect for the compounds that we use and not just dismiss every piece of evidence as bullshit, we must learn from the evidence wich ever way it may lean towards to help us make our own decisions.

FAT BOY · 17-04-2006, 12:39 PM

good post caymen

***Extreme*** · 23-04-2006, 12:39 AM

Caymen, you shouln't have been using at 18yr old in the first place, thats asking for trouble if you ask me, or pretty much anyone else for that matter.

www.extremenutrition.co.uk

Caymen · 23-04-2006, 01:04 AM

you have just confirmed what im saying extreme, you see if id would have access to the info thats being put on here then it would have been different story, but no all i had was the guys with the gung ho aproach that some are showing on here and thats when the sh1it hits the fan, its ok saying i shouldnt be using at the age of 18 but that doesnt make any difference to how i react personaly to clenbuterol as it can be a nasty compound to some people whatever the age, i think education is the key not just accepting all the good bits and dismissing the bad bits, education is what we should be giving to the younger up and coming guys and girls so they dont rush in and cause damage to themselves.

15-04-2006, 01:16 AM	#4 (permalink)
Nick500 Join Date: Aug 2004 Location: Bristol Posts: 3,230 Rep Power:	Sideeffects of Clen (another source...): Clenbuterol is a popular - but banned - drug used by athletes in body-building, power-related, and even endurance sports. The chemical is attractive to athletes because it appears to have an anabolic effect on human muscles, and it may also increase fat metabolism. However, the actual effects of long-term clenbuterol intake on performance, muscle power, and overall health have been unclear. To determine some of clenbuterol's actions, scientists at the University of Melbourne in Australia recently gave clenbuterol to laboratory rats at dosages of 2 milligrams per kilogram of body weight per day. Some of the rats followed a completely sedentary lifestyle, while others sprinted on treadmills or engaged in endurance swim training. Clenbuterol did have a couple of potentially positive effects: Sedentary rats which ingested clenbuterol had larger muscles than clenbuterol-free, sedentary rodents, and clenbuterol users also transformed leg-muscle cells from slow-twitch to fast-twitch fibres, a surprising change which would tend to increase anaerobic energy production and magnify muscle power during short, intense exertions. However, clenbuterol also yielded three very negative changes. First, after just four weeks, clenbuterol-treated rats were unable to maintain their normal swimming or running training intensities, while clean rodents were quite capable of continuing. Secondly, the hearts of the clenbuterol-taking, trained rats increased dramatically in size compared to the hearts of sedentary rats, but the heart expansion was probably due to the infiltration of collagen fibres into the heart walls, not an increase in heart-muscle cells. Collagen is a tough connective tissue which doesn't augment heart-muscle power but in fact stiffens the heart, potentially leading to a decrease in cardiac output. Increases in collagen may also produce cardiac arrhythmias. Thirdly, clenbuterol rats suffered from noticeable cardiac-cell degeneration. In addition, although sedentary, clenbuterol-treated rats were more muscular than clenbuterol-free, sedentary rats, clenbuterol was unable to boost muscle mass among either the swim- or treadmill-trained rodents. It appears that, in spite of its popularity, clenbuterol is a potentially dangerous drug which offers very few positive effects for either the power or endurance athlete. ('The Effects of Clenbuterol on Skeletal and Cardiac Muscle of Rats when Combined with Aerobic and Anaerobic Exercise, ' Biochemistry of Exercise Ninth International Conference Abstracts, #117, p 75, 1994) ______________________ - Obsession is what lazy people call dedication -

17-04-2006, 12:51 AM	#6 (permalink)
*Extreme* Super Moderator Super Moderator Join Date: Oct 2004 Location: UK Posts: 1,334 Rep Power:	Ok, can I nail this thread shut? What dose of clen do people commonly use? 0.4mcg up to 2mcg PER PERSON! The doses of stuff they give these rats is bound to fukk em up, its ridiculous and not even worth comparing to that being used in the real world of performance/aesthetic enhancement. www.extremenutrition.co.uk ______________________ www.extremenutrition.co.uk - 25% OFF FOR ALL MC MEMBERS, discount code MCD25. www.betterbodies.uk.com Seriously cheap sports nutrition! DYNALYNE, the strongest fat burner ever, ONLY £24.95!

23-04-2006, 12:39 AM	#9 (permalink)
*Extreme* Super Moderator Super Moderator Join Date: Oct 2004 Location: UK Posts: 1,334 Rep Power:	Caymen, you shouln't have been using at 18yr old in the first place, thats asking for trouble if you ask me, or pretty much anyone else for that matter. www.extremenutrition.co.uk ______________________ www.extremenutrition.co.uk - 25% OFF FOR ALL MC MEMBERS, discount code MCD25. www.betterbodies.uk.com Seriously cheap sports nutrition! DYNALYNE, the strongest fat burner ever, ONLY £24.95!

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15-04-2006, 01:00 AM	#2 (permalink)
funbos Making Progress Join Date: Jul 2005 Location: A hell of a place to make my fortune. Posts: 226 Rep Power:	one of my dogs was eat one box/plastic jar of jing tan clen ( IMO the best on the market ) i was afraid for him but now all its ok with him

15-04-2006, 01:02 AM	#3 (permalink)
razg Legend Join Date: Nov 2004 Location: Birmingham/Bristol Posts: 886 Rep Power:	LOL. Reminds me of "My dog ate my dbol" thread - dogs are amazingly tough creatures.

15-04-2006, 03:39 PM	#5 (permalink)
Young Gun Illuminati Join Date: Apr 2005 Posts: 1,539 Rep Power:	Another for the I don't care locker. I don't see people dropping dead from clen induced heart attacks and I could get about 5 studies to show that the levels of potassium in banana's are a potential cancer risk. At the end of the day the only people at a serious risk from drug abuse is those who abuse them. Bodybuilding use IMO is nowhere near abuse, maybe I should do a check to find out how likely it is that I may be in a car accident on the way to buy it?

17-04-2006, 02:21 AM	#7 (permalink)
Caymen Making Progress Join Date: Dec 2005 Location: www.PureMuscle.co.uk Posts: 435 Rep Power:	To put it short Clen put me in hospital with suspected heart attack at 18 years old, very low dose also, the Cardiologist told me that my heart wasnt pumping blood properly because of the effect clen was having on me, im just one of the unlucky ones that dont get along with clen. we shouldnt live in a state of denial were steroids and related compounds are concerned!, they can have a negative effect on some people were the majority get away with it but we all need to have respect for the compounds that we use and not just dismiss every piece of evidence as bullshit, we must learn from the evidence wich ever way it may lean towards to help us make our own decisions.

17-04-2006, 12:39 PM	#8 (permalink)
FAT BOY Legend Join Date: Dec 2005 Location: UK Posts: 853 Rep Power:	good post caymen

23-04-2006, 01:04 AM	#10 (permalink)
Caymen Making Progress Join Date: Dec 2005 Location: www.PureMuscle.co.uk Posts: 435 Rep Power:	you have just confirmed what im saying extreme, you see if id would have access to the info thats being put on here then it would have been different story, but no all i had was the guys with the gung ho aproach that some are showing on here and thats when the sh1it hits the fan, its ok saying i shouldnt be using at the age of 18 but that doesnt make any difference to how i react personaly to clenbuterol as it can be a nasty compound to some people whatever the age, i think education is the key not just accepting all the good bits and dismissing the bad bits, education is what we should be giving to the younger up and coming guys and girls so they dont rush in and cause damage to themselves.