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18-03-2005, 06:10 PM
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| Making Progress Join Date: Mar 2005 Location: Way Out West Posts: 578 Rep Power:  |  Frontloading Basics and Dosages Frontloading Basics and Dosages by Curls4dGirls at SuperiorMuscle.com with contributions by Skyefire and Spidey The purpose of this thread is to provide some basic information on frontloading, including an explanation of half-lives, differences across esters, and recommended frontloading dosages. HALF-LIFE BASICS Each compound includes an ester that, along with other factors, controls the release of the hormone into the system. The rate of release differs by ester and is defined in terms of half-life. The average half-lives of esters are: ESTER HALF LIFE (days) Formate 1.5 Acetate 3 Propionate 4.5 Butyrate 6 Valerate 7.5 Hexanoate 9 Caproate 9 Isocaproate 9 Heptanoate 10.5 Enanthate 10.5 Octanoate 12 Cypionate 12 Nonanoate 13.5 Decanoate 15 Undecanoate 16.5 The half-life is the length of time (in days) to release half of the hormone into the system. For example, if 500 mgs of Testosterone Cypionate is administered, in 12 days, on average, 250 mgs of testosterone has been released into the system and 250 mgs of testosterone remains attached to the ester. In another 12 days, an additional 125 mgs (half of the remaining 250 mgs) has been released into the system for a total of 375 mgs released and 125 mgs still attached to the ester. The key detail is that different esters release the hormone into the system at different rates. Therefore, different esters require different frontload dosages. FRONTLOADING The purpose of frontloading is to quickly reach the target dosage to more quickly realize the benefits of the AAS. This thread provides instructions to reach 75% of the weekly dosage within the first week Most people use, as a rule of thumb, twice the weekly dosage (double dosing) in the first week. That works well for esters with a half-life of 10.5 days or less. However, this does not work well for longer esters. Lets look at EQ as an example. If the intended weekly dosage is 600 mgs, then the frontload dosage, based on double dosing, is 1200 mgs. Although 50% of the intended dosage is reached in the first week, 75% of the intended dosage is not reached until week 4. Without any frontloading, 75% of the intended dosage is reached in week 5. So, while double dosing works, the effects diminish with increasing half-life. EQ Double Dose Values at 600 mgs (1200 mgs in Week 1) No Frontload Released % of Target Week 1 153 25% Week 2 267 44% Week 3 352 59% Week 4 415 69% Week 5 462 77% Week 6 497 83% Double Dosing Released % of Target Week 1 306 51% Week 2 381 63% Week 3 437 73% Week 4 478 80% Week 5 509 85% Week 6 532 89% The following table includes frontloading dosage to reach 75% of the intended dosage by the end of the first week. The dosages are indexed at 100 mgs / week. To reach your intended dosage, simply multiply the frontload dosage by your weekly dosage divided by 100. For example, if you wanted to run Testosterone Cypionate at 800 mgs / wk, then multiply the frontload dosage of 225 mgs by 8 (800 / 100) for 1800 mgs in week 1. ESTER FRONTLOAD DOSAGE(mgs) Formate 100 Acetate 100 Propionate 115 Butyrate 130 Valerate 160 Hexanoate 180 Caproate 180 Isocaproate 180 Heptanoate 200 Enanthate 200 Octanoate 225 Cypionate 225 Nonanoate 250 Decanoate 270 Undecanoate 295 The calculation used is MgDL = MgD * (1/2)^(D/HL), where: MgDL = Mgs of depot left MgD = Mgs in depot (total) D = Days H = Half-life Injections for Formate and Acetate are daily. Injections for Propianate are every other day. Injections for Butyrate are every 3 days. All other esters are administered as one injection at the beginning of the week 1. It should be noted that injection frequency does not significantly influence frontloading dosages. |
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