CoQ10 Fact or Fiction

bushidodad · 17-01-2007, 07:01 PM

I got a guy who has for the past 3 days been preaching about coq10. I looked around and could not find any tests that had any orginal information. Just b4llsh1t advertising and links to half as experiments. Has anyone had any experience with it (not what you've heard)?
If you got a sec let me know. I need to shut him by agreeing or arguing either will do. Thanx

**Neil R** · 17-01-2007, 08:11 PM

It is an essential co-factor in the electron transport mechanism, which ties to Krebs cycle, therefore being an essential component in ATP re-synthesis. It has loads of applications, I'll copy a bit from my wee research library I have on my PC....

Quote:

Coenzyme Q10, also known as CoQ10, is a normal and essential component of the membranes of mitochondrial the intracellular organelles that manufacture ATP, the basic energy molecule of the cell. CoQ10 plays a critical role in the production of energy in nearly every cell of the body, and is found in most living
systems.

For this reason, it was named ubiquinone (for ubiquitous quinone) by its discoverer, R.A. Morton. CoQ10 has been shown to improve many conditions associated with aging, and to extend the lifespan of several organisms.

Mechanisms of Action
CoQ10 is a vitamin-like fat-soluble nutrient (quinone) and functions as an important component of the mitochondrial energy electron transduction chain (oxidative phosphorylation) and in the production of adenosine triphosphate (ATP).

CoQ10 is a powerful antioxidant, capable of inhibiting lipid peroxidation in mitochondrial membranes (its chemical structure is similar to that of Vitamin E). It has
cardioprotective, cytoprotective, and neuroprotective properties, is a calcium channel blocker and membrane stabilizer, modulates prostaglandins, inhibits intracellular phospholipases and preserves myocardial NaK-ATPase.1

Clinical Uses of CoQ10

Congestive Heart Failure
A number of studies have confirmed CoQ10s effectiveness in improving cardiac function in cases of cardiomyopathy and congestive heart failure. In one six-year study of 122 patients with New York Heart Association classes II, III and IV chronic dilated cardiomyopathy, subjects were treated with 100 mg CoQ10 each day. At the beginning of the study, the mean ejection fraction a measure of ventricular blood flow was 41 percent. Ejection fraction increased to 59 percent after only six months on CoQ10. Eighty-seven percent of the participants experienced significant improvement in their ejection fraction during this time, and improved by one or two New York Heart Association classes. Those in class II achieved the greatest benefit. All of these subjects became asymptomatic after CoQ10 administration. Despite these positive results, the authors suggested that the 100 mg dose of CoQ10 was too low, and the subjects might have done even better on higher doses.2

Angina Pectoris
Angina pectoris is chest pain caused by decreased blood flow (and decreased oxygenation) of the heart. In an early Japanese study, 12 patients (average age 56 years) with stable angina were given 150 mg of CoQ10 per day for four weeks. CoQ10 reduced anginal frequency and nitroglycerin use and increased exercise time and time to ST-segment depression.3 (ST-segment is an abnormality on an electrocardiogram indicating the heart is not getting enough oxygen, presenting an increased risk of heart attack.) These results were confirmed in more recent studies, using doses ranging from 30 to 600 mg per day.4

Hypertension
CoQ10 is also helpful in hypertension. In mild or borderline cases, it may be all that is needed. For example, in one study conducted at the Department of Veterans Affairs Medical Center in Boise, Idaho, physicians administered 120 mg of CoQ10 to 46 male and 37 female hypertensive patients (mean age was nearly 70 in both cases). Systolic
blood pressure was reduced by an average of 17.8 mmHg.5 Australian researchers obtained similar blood-pressure-lowering results with a dose of 200 mg CoQ10 in 74 hypertensive diabetics.6

Protection Against Statin Toxicity
Statins, or 3-hydroxy-3-methylglutaryl Co A (HMG-CoA) reductase inhibitors, are effective drugs for lowering cholesterol. However, published data confirm that statins can cause myopathies (muscle disease), rhabdomyolysis (muscle damage), and renal failure. In May 2000, the FDA warned about liver failure with regard to statin drugs. Statins have been associated with an increased incidence of cataracts, cancer, peripheral neuropathies and some psychiatric disturbances.

Statins lower CoQ10 levels in the heart, skeletal and liver tissues. In mice, statins lower ATP levels, and impair energy metabolism. Although package inserts and marketing material do not mention the statins-CoQ10 link, two U.S. patents filed in January and February of 1989 and granted in 1990 describe a method for counteracting statin-associated myopathy and potential liver damage by concurrent administration of the statins with CoQ10. Both of these patents were assigned to Merck & Co.

However, for more than 14 years, the producers of statins have not acted upon this information and failed to reveal the statin-CoQ10 relation to millions of statin users and to the medical community.

The concern by physicians and scientists regarding the depletion of CoQ10 by the statins is growing from a level of concern to one of alarm.

With ever higher statin potencies and dosages, and with a steadily shrinking target LDL cholesterol, the prevalence and severity of CoQ10 deficiency is increasing noticeably.

An estimated 36 million Americans are now using statin drug therapy. Statin-induced CoQ10 depletion is well documented in animal and human studies with detrimental cardiac consequences in both animal models and human trials. This drug-induced nutrient deficiency is dose-related and more notable in settings of pre-existing CoQ10 deficiency such as in the elderly and in heart failure.

We are currently in the midst of a congestive heart failure epidemic in the United States, and this epidemic may be due, in large part, to the excessive use of statin
drugs and inadequate use of CoQ10.7

Neurologic and Neurodegenerative Disorders
CoQ10 has the potential to be a beneficial agent in any neurodegenerative disease which is characterized by impaired mitochondrial function and/or excessive oxidative damage. CoQ10 has been found to be protective against neuronal toxins in animal models of Parkinsons disease, amyotrophic lateral sclerosis and Huntingtons disease.8

Recent clinical trials in these disorders demonstrate that supplemental CoQ10 can slow functional decline particularly of Parkinsons disease.9 Parkinsons is a degenerative neurological disorder for which no treatment has been shown to slow its progression. Nevertheless, in a large, multicenter study, 80 subjects with early Parkinsons were
administered CoQ10 at dosages of 300, 600 or 1,200 mg per day. They were followed for 16 months. Those who received CoQ10 experienced less disability than those who received the placebo, and the benefit was greatest in those who received the highest dosage.10

A short confirmatory study was conducted by scientists in Germany, giving CoQ10 in daily doses of 360 mg for four weeks to 28 Parkinsons patients. CoQ10 supplementation provided a mild but significant symptomatic benefit on Parkinsons symptoms and a significantly better improvement in performance compared with placebo.11

Diabetes
Australian researchers recently reported a reduction of glycosylated hemoglobin (HbA1c an indicator of blood sugar control) in a large group of hypertensive diabetics who received a daily CoQ10 dosage of 200 mg per day.6

Cancer
In 1994, a dramatic report of two cancer patients treated with CoQ10 was published.12 The first was of a 59-year-old woman who had intraductal carcinoma (cancer) of the left breast, which resolved completely on a daily dose of 390 mg CoQ10. A second patient, after breast surgery, was found to have residual intraductal carcinoma in the tumor bed. She refused additional surgery, and was placed on 300 mg CoQ10 per day.

Over a year later, there was no evidence of residual tumor or metastases. Despite practicing oncology for 35 years, over which he had treated about 200 cases of breast cancer per year, one of the authors commented that he had never [before] seen a spontaneous complete regression of a 1.5-2.0 cm breast tumor and ha[d] never seen a comparable regression on any conventional anti-tumor therapy.

A more recent study indicated that breast cancer is associated with a decrease of plasma CoQ10 levels, and the worse the cancer, the greater the decrease in
CoQ10.13

Periodontal Disease
CoQ10 is dramatically effective in treating periodontal disease, a common malady of aging. In an early study, eight patients received CoQ10 at 25 mg, twice a day, versus a placebo group. The results showed a reduction in pocket depth with photographic evidence of improved gingival health.14 In a more recent study, CoQ10 was used topically, with significant improvement.15

Renal Failure
Dr. Ram B. Singh of the Heart Research Laboratory and Center for Nutrition in Moradabad, India, reported on a new indication for CoQ10 therapy, in a patient with acute glomerulonephritis, renal failure and high levels of lipid peroxides. He administered 180 mg per day of CoQ10, with a resultant lowering of lipid peroxides and significant improvement in renal function.16

In a follow-up study of 11 patients with chronic renal failure (serum creatinine levels were 5 mg/dL or above) who were on intermittent dialysis, Dr. Singh again administered CoQ10 at a dosage of 180 mg per day. After four weeks of treatment, the patients experienced significant reductions in serum creatinine and blood urea and significant increases in creatinine clearance and urine output, and fewer subjects required dialysis.17

bushidodad · 18-01-2007, 01:47 PM

With an English accent, "Thank you doctor"
That's great, it sounds like a wonder drug. I haven't found any adverse effects no matter what the dose. I seems the more severe an illness the more the doctors administer to the patient.

Thanx alot, top notch educational material.
The guy in my office is getting his CoQ10 from Walmart. Do you know of a better distributor for the gel CoQ10? Just incase I want to start taking it.

Thanx again

architekt · 18-01-2007, 05:44 PM

Quote:

Originally Posted by Neil R

I'll copy a bit from my wee research library I have on my PC....

bladdy 'ell!!....just a wee bit then!

very informative though!

**Neil R** · 18-01-2007, 09:20 PM

http://www.google.co.uk/search?hl=en...e+Search&meta=

***Extreme*** · 18-01-2007, 10:17 PM

I've not read Neils post fully but 5 years ago I was given a year to live (for those who haven't heard this old chestnut) when a hole was discovered in my heart due to a birth defect.

I did a lot of research into what I could do to try and strengthen my heart which was 20% functional and CoQ10 was one of the things I found. It is stored primarily in your gums and heart due to them being made of the same tissue, the only 2 parts of the body which are. If you brush your teeth and your gums bleed this can be a sign of CoQ10 deficiency, if the gums are deficient so will the heart be.

I stacked it with EFA's to help prevent arterial clogging and odourless garlic capsules to thin my blood so it was easier for my heart to pump.

I am still using EFA's and CoQ10 5 years later after them deciding 7 months after diagnosis my heart had gone up to 40% efficiency and could handle the operation giving me a 75% survival chance. The op went well and 4 years after my op my heart has returned to near normal function albeit with a titanium aorta. This is with me still using small amounts of anabolics (no androgens bcos they interact with my warfarin) and a little GH now and again, the doctors told me they didn't think it would be wise for me to train again but now they have told me "Whatever it is you are doing, keep doing it because the transformation in your heart is miraculous. We never expected you to recover to this degree and we don't know why or how you have"

My cardiologist addmitted the UK is 10 years behind America and Japan and the Japs are big into CoQ10, thats where I discovered it could help me. I truly believe with the pitfalls of modern life our diets are ALL deficient in something as food is tampered with too much by man and things like EFA'S CoQ10 and various other things can help redress the balance of our modern diets.

**LeeB** · 19-01-2007, 09:50 AM

Quote:

Originally Posted by Extreme

I've not read Neils post fully but 5 years ago I was given a year to live (for those who haven't heard this old chestnut) when a hole was discovered in my heart due to a birth defect.

I did a lot of research into what I could do to try and strengthen my heart which was 20% functional and CoQ10 was one of the things I found. It is stored primarily in your gums and heart due to them being made of the same tissue, the only 2 parts of the body which are. If you brush your teeth and your gums bleed this can be a sign of CoQ10 deficiency, if the gums are deficient so will the heart be.

I stacked it with EFA's to help prevent arterial clogging and odourless garlic capsules to thin my blood so it was easier for my heart to pump.

I am still using EFA's and CoQ10 5 years later after them deciding 7 months after diagnosis my heart had gone up to 40% efficiency and could handle the operation giving me a 75% survival chance. The op went well and 4 years after my op my heart has returned to near normal function albeit with a titanium aorta. This is with me still using small amounts of anabolics (no androgens bcos they interact with my warfarin) and a little GH now and again, the doctors told me they didn't think it would be wise for me to train again but now they have told me "Whatever it is you are doing, keep doing it because the transformation in your heart is miraculous. We never expected you to recover to this degree and we don't know why or how you have"

My cardiologist addmitted the UK is 10 years behind America and Japan and the Japs are big into CoQ10, thats where I discovered it could help me. I truly believe with the pitfalls of modern life our diets are ALL deficient in something as food is tampered with too much by man and things like EFA'S CoQ10 and various other things can help redress the balance of our modern diets.

you missed the boat there... you could have put your whole recovery down to extreme nutrition supplements!! lol

bushidodad · 19-01-2007, 07:26 PM

That's funny Lee.

Thanx Extreme, I have done some additional research and asked a few people including my doc and everyone said it is a miracle drug.

You said it helped with a hole in your heart. My daughter at the age of 5 has a heart murmur too. So far I have not read anything saying not to give it to children. Her doctor told me she would probably grow out of it, but she does not gain weight. That's one of the possible side effects. One ventricle pumps harder to compensate for the pressure of the other one. So it burns more calories. That's why my daughter has a six pack and weighs 37 lbs. I have tried everything with her diet to help her gain some good weight, but have had no success.
If anyone knows anything or knows where I could do some research, please let me know.
Thanx

***Extreme*** · 21-01-2007, 08:09 PM

A murmur is a wide ranging term but not specific enough to tell me what the problem is and if it was similar to mine.

I was born with one of the cusps off the aorta not fully formed, my problem was it should be a non return valve but the flap that should close over after each beat so the heart pulls freshly oxygenated blood along from the lungs didn't form properly so after every beat my heart sucked back in some of the blood it pumped out.

My heart was naturally enlarging to compensate for not enough blood going round my body, but as it got bigger so did the amount of backwash so the problem got worse too as the chambers elarged they could hold more blood either from the lungs or from the backwash.

They installed a metal aorta and this has fixed the problem but has totally changed my lifestyle.

If you can tell me more I will see if I can advise in any way, I've done a lot of research into cardiac issues so I could make intelligent decisions regading my own situation.

bushidodad · 22-01-2007, 04:39 PM

I believe that there is a hole between ventricles and one ventricle is pumping harder to keep pressure on the other. I believe this is the problem. Thanx for the help. I really think she could benefit from a little CoQ10.

17-01-2007, 07:01 PM	#1 (permalink)
bushidodad Making Progress Join Date: Nov 2006 Location: USA Posts: 131 Rep Power:	CoQ10 Fact or Fiction I got a guy who has for the past 3 days been preaching about coq10. I looked around and could not find any tests that had any orginal information. Just b4llsh1t advertising and links to half as experiments. Has anyone had any experience with it (not what you've heard)? If you got a sec let me know. I need to shut him by agreeing or arguing either will do. Thanx ______________________ Socrates believed that a man would make the right decision if he knew all aspects of the situation. I am in search for all of those aspects.

18-01-2007, 01:47 PM	#3 (permalink)
bushidodad Making Progress Join Date: Nov 2006 Location: USA Posts: 131 Rep Power:	Re: CoQ10 Fact or Fiction With an English accent, "Thank you doctor" That's great, it sounds like a wonder drug. I haven't found any adverse effects no matter what the dose. I seems the more severe an illness the more the doctors administer to the patient. Thanx alot, top notch educational material. The guy in my office is getting his CoQ10 from Walmart. Do you know of a better distributor for the gel CoQ10? Just incase I want to start taking it. Thanx again ______________________ Socrates believed that a man would make the right decision if he knew all aspects of the situation. I am in search for all of those aspects.

18-01-2007, 09:20 PM	#5 (permalink)
Neil R Moderator Musclechat Icon Join Date: Oct 2006 Posts: 645 Rep Power:	Re: CoQ10 Fact or Fiction http://www.google.co.uk/search?hl=en...e+Search&meta= ______________________ APPLIED KNOWLEDGE, IS POWER!!! The real challenge is to be yourself in a world that wants you to be someone else!!

18-01-2007, 10:17 PM	#6 (permalink)
*Extreme* Super Moderator Super Moderator Join Date: Oct 2004 Location: UK Posts: 1,304 Rep Power:	Re: CoQ10 Fact or Fiction I've not read Neils post fully but 5 years ago I was given a year to live (for those who haven't heard this old chestnut) when a hole was discovered in my heart due to a birth defect. I did a lot of research into what I could do to try and strengthen my heart which was 20% functional and CoQ10 was one of the things I found. It is stored primarily in your gums and heart due to them being made of the same tissue, the only 2 parts of the body which are. If you brush your teeth and your gums bleed this can be a sign of CoQ10 deficiency, if the gums are deficient so will the heart be. I stacked it with EFA's to help prevent arterial clogging and odourless garlic capsules to thin my blood so it was easier for my heart to pump. I am still using EFA's and CoQ10 5 years later after them deciding 7 months after diagnosis my heart had gone up to 40% efficiency and could handle the operation giving me a 75% survival chance. The op went well and 4 years after my op my heart has returned to near normal function albeit with a titanium aorta. This is with me still using small amounts of anabolics (no androgens bcos they interact with my warfarin) and a little GH now and again, the doctors told me they didn't think it would be wise for me to train again but now they have told me "Whatever it is you are doing, keep doing it because the transformation in your heart is miraculous. We never expected you to recover to this degree and we don't know why or how you have" My cardiologist addmitted the UK is 10 years behind America and Japan and the Japs are big into CoQ10, thats where I discovered it could help me. I truly believe with the pitfalls of modern life our diets are ALL deficient in something as food is tampered with too much by man and things like EFA'S CoQ10 and various other things can help redress the balance of our modern diets. ______________________ www.extremenutrition.co.uk - 25% OFF FOR ALL MC MEMBERS, discount code MCD25. www.betterbodies.uk.com Seriously cheap sports nutrition! Dorian Yates Ultimate Protein 908g with free T-shirt £17.95!

19-01-2007, 07:26 PM	#8 (permalink)
bushidodad Making Progress Join Date: Nov 2006 Location: USA Posts: 131 Rep Power:	Re: CoQ10 Fact or Fiction That's funny Lee. Thanx Extreme, I have done some additional research and asked a few people including my doc and everyone said it is a miracle drug. You said it helped with a hole in your heart. My daughter at the age of 5 has a heart murmur too. So far I have not read anything saying not to give it to children. Her doctor told me she would probably grow out of it, but she does not gain weight. That's one of the possible side effects. One ventricle pumps harder to compensate for the pressure of the other one. So it burns more calories. That's why my daughter has a six pack and weighs 37 lbs. I have tried everything with her diet to help her gain some good weight, but have had no success. If anyone knows anything or knows where I could do some research, please let me know. Thanx ______________________ Socrates believed that a man would make the right decision if he knew all aspects of the situation. I am in search for all of those aspects.

21-01-2007, 08:09 PM	#9 (permalink)
*Extreme* Super Moderator Super Moderator Join Date: Oct 2004 Location: UK Posts: 1,304 Rep Power:	Re: CoQ10 Fact or Fiction A murmur is a wide ranging term but not specific enough to tell me what the problem is and if it was similar to mine. I was born with one of the cusps off the aorta not fully formed, my problem was it should be a non return valve but the flap that should close over after each beat so the heart pulls freshly oxygenated blood along from the lungs didn't form properly so after every beat my heart sucked back in some of the blood it pumped out. My heart was naturally enlarging to compensate for not enough blood going round my body, but as it got bigger so did the amount of backwash so the problem got worse too as the chambers elarged they could hold more blood either from the lungs or from the backwash. They installed a metal aorta and this has fixed the problem but has totally changed my lifestyle. If you can tell me more I will see if I can advise in any way, I've done a lot of research into cardiac issues so I could make intelligent decisions regading my own situation. ______________________ www.extremenutrition.co.uk - 25% OFF FOR ALL MC MEMBERS, discount code MCD25. www.betterbodies.uk.com Seriously cheap sports nutrition! Dorian Yates Ultimate Protein 908g with free T-shirt £17.95!

22-01-2007, 04:39 PM	#10 (permalink)
bushidodad Making Progress Join Date: Nov 2006 Location: USA Posts: 131 Rep Power:	Re: CoQ10 Fact or Fiction I believe that there is a hole between ventricles and one ventricle is pumping harder to keep pressure on the other. I believe this is the problem. Thanx for the help. I really think she could benefit from a little CoQ10. ______________________ Socrates believed that a man would make the right decision if he knew all aspects of the situation. I am in search for all of those aspects.

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