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axalotl2000 · 17-10-2007, 06:25 AM

Daily requirement
Pantothenate in the form of pantethine is considered to be the more active form of the vitamin in the body, but is unstable at high temperatures or when stored for long periods, so calcium pantothenate is the more usual form of vitamin B5 when it is sold as a dietary supplement. 10 mg of calcium pantothenate is equivalent to 9.2 mg of pantothenic acid.

Age group Age Requirements
(in mg per day)

infants 0-6 months 1.7
infants 7-12 months 2
children 4-8 years 3
children 9-13.5 years 4
adolescents 14-18 years 5
adults 19 years and older 5
pregnant women 6
breastfeeding women 7

United Kingdom RDA: 6 mg/day
Acne
Following from discoveries in mouse trials,[citation needed] in the late 1990s a small study was published promoting the use of pantothenic acid to treat acne vulgaris.

According to a study published in 1995 by Dr. Lit-Hung Leung,[6] high doses of Vitamin B5 resolved acne and decreased pore size. Dr. Leung also proposes a mechanism, stating that CoA regulates both hormones and fatty-acids, and without sufficient quantities of pantothenic acid, CoA will preferentially produce androgens.[citation needed] This causes fatty acids to build up and be excreted through sebaceous glands, causing acne.[citation needed] Leung's study gave 45 Asian males and 55 Asian females varying doses of 10-20g of pantothenic acid (100,000%-200,000% of the US Daily Value), 80% orally and 20% through topical cream. Leung noted improvement of acne within one week to one month of the start of the treatment.[citation needed]

Critics are quick to point out the flaws in Dr. Leung's study, however. Dr. Leung's study was not a double-blind placebo controlled trial. To date, the only study looking at the effect of Vitamin B5 on acne is Dr. Leung's, and few if any dermatologists prescribe high-dose pantothenic acid. Furthermore, there is no evidence documenting acetyl-CoA regulation of androgens instead of fatty acids in times of stress or limited availability, since fatty acids are also necessary for life.

17-10-2007, 06:25 AM	#2 (permalink)
axalotl2000 Making Progress Join Date: Jan 2005 Posts: 202 Rep Power:	Re: Vitamin B5 Daily requirement Pantothenate in the form of pantethine is considered to be the more active form of the vitamin in the body, but is unstable at high temperatures or when stored for long periods, so calcium pantothenate is the more usual form of vitamin B5 when it is sold as a dietary supplement. 10 mg of calcium pantothenate is equivalent to 9.2 mg of pantothenic acid. Age group Age Requirements (in mg per day) infants 0-6 months 1.7 infants 7-12 months 2 children 4-8 years 3 children 9-13.5 years 4 adolescents 14-18 years 5 adults 19 years and older 5 pregnant women 6 breastfeeding women 7 United Kingdom RDA: 6 mg/day Acne Following from discoveries in mouse trials,[citation needed] in the late 1990s a small study was published promoting the use of pantothenic acid to treat acne vulgaris. According to a study published in 1995 by Dr. Lit-Hung Leung,[6] high doses of Vitamin B5 resolved acne and decreased pore size. Dr. Leung also proposes a mechanism, stating that CoA regulates both hormones and fatty-acids, and without sufficient quantities of pantothenic acid, CoA will preferentially produce androgens.[citation needed] This causes fatty acids to build up and be excreted through sebaceous glands, causing acne.[citation needed] Leung's study gave 45 Asian males and 55 Asian females varying doses of 10-20g of pantothenic acid (100,000%-200,000% of the US Daily Value), 80% orally and 20% through topical cream. Leung noted improvement of acne within one week to one month of the start of the treatment.[citation needed] Critics are quick to point out the flaws in Dr. Leung's study, however. Dr. Leung's study was not a double-blind placebo controlled trial. To date, the only study looking at the effect of Vitamin B5 on acne is Dr. Leung's, and few if any dermatologists prescribe high-dose pantothenic acid. Furthermore, there is no evidence documenting acetyl-CoA regulation of androgens instead of fatty acids in times of stress or limited availability, since fatty acids are also necessary for life.