Interesting, but there is no evidence to suggest that GH is actually anabolic - these effects are supposed to be mediated through increased hepatic IGF-1, yet studies have shown that even in cases where hepatic IGF-1 is not produced, skeletal muscle growth is normal.
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Originally Posted by Nandi 2) GH administration builds muscle mass
No studies have ever confirmed this. Several have refuted it. Hepatic IGF-1 is probably not important to muscle growth |
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Originally Posted by Nandi Well, in rats that are engineered not to produce hepatic IGF, growth of the rats, including skeletal muscle development, is still normal. This sugggests that liver produced IGF is not very significant for muscle development. This jibes with the results of studies that show exogenous GH has no effect on muscle anabolism in humans. |